There have been increasing reports of ATRA-induced myositis, with its frequent association with retinoic acid syndrome and Sweet's syndrome. The use of all-trans retinoic acid (ATRA) is now standard therapy for the treatment of acute promyelocytic leukaemia (APML). We present an analysis of the incidence, char-Ī case of all-trans retinoic acid-induced myositis in the treatment of acute promyelocytic leukaemia.
Detailed knowl- edge about DS has remained limited. TextabstractDifferentiation syndrome (DS) can be a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy with all- trans retinoic acid (ATRA). These data establish that all-trans-retinoic acid, 13-cis- retinoic acid, and retinoyl glucuronide are physiological metabolites of vitamin A in target tissues, and therefore are important candidates as mediators of the biological effect of the vitaminĭifferentiation syndrome in patients with acute promyelocytic leukemia treated with all- trans retinoic acid and anthracycline chemotherapy: Characteristics, outcome, and prognostic factors An examination of retinyl acetate metabolites under steady state conditions in vitamin A-repleted rats demonstrates the occurrence of all-trans-retinoic acid and 13-cis- retinoic acid in circulation and in intestinal epithelium, in a pattern similar to that found after injection of retinoic acid into vitamin A-depleted rats. Retinoyl glucuronide, the major metabolite of retinoic acid intestinal epithelium, in contrast to other polar metabolites, was not detected in circulation.
Retinoyl glucuronide and 13-cis- retinoic acid are early metabolites of all-trans-retinoic acid in the small intestine of bile duct-cannulated rats. All-trans-retinoic acid appears in small intestinal epithelium within 2 min after dosing and is the major radioactive compound there for at least 2 h.
A major portion of intrajugularly injected retinoic acid is rapidly (within 2 min) sequestered by tissues subsequently 13-cis- retinoic acid and polar metabolites are released into circulation. The kinetics and metabolism of physiological doses of all-trans-retinoic acid were examined in blood and small intestinal mucosa of vitamin A-depleted rats. International Nuclear Information System (INIS) Demonstration of common physiological metabolites in rat small intestinal mucosa and circulation Metabolism of all-trans-retinoic acid and all-trans-retinyl acetate.
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